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New SPCG paper. With the Bokinsky lab (Milan Lacassin), Andrea Ripamonti modeled the competition for transcriptional resources. Our data and model jointly show how E. coli’s second messengers ppGpp & cAMP reshape gene expression globally. www.sciencedirect.com/science/arti...
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Cells regulate gene expression by balancing transcriptional resources across different functional groups of genes. In Escherichia coli, second messeng…
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Transcriptional competition biases the effects of second messengers in Escherichia coli
Statistical Physics of Cells and Genomes