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Our work on optimal treatment in presence of cancer persisters is out today in @prxlife.bsky.social 🎉 Alternated drug-release periods may be an advantage due to dose-dependent transition rates and slow death of persisters journals.aps.org/prxlife/abst...
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journals.aps.org
Extending persistence modeling to drug-induced, dose-dependent cancer persistence reveals that strategic drug holidays and reduced doses can improve long-term treatment outcomes.
Optimal Treatment for Drug-Induced Cancer Persisters Involves Release Periods and Intermediate Drug Doses
Statistical Physics of Cells and Genomes