Group leader, RNA and cellular adaptation in fungi. Carpentries data science instructor. Trying to make my corner of science a better place. Opinions my own.
https://ewallace.github.io
Edward Wallace
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I am learning a lot from this debate about the last eukaryotic common ancestor. It's thought-provoking to have competing hypotheses and perspectives argued out there in the open.
Here, the two arguments are internally consistent, yet different conclusions... so where's the wrong assumption?
Edward Wallace
We are hiring a postdoctoral researcher to investigate ribosome hibernation and activation in microsporidia using confocal microscopy, soft X-ray tomography, cryo-electron tomography, and omics approaches. If you are interested, apply here: jobs.exeter.ac.uk/hrpr_webrecr...
Today's @gautamdey.bsky.social seminar on Evolutionary Cell Biology is mind-blowing in so many ways.
Dinoflagellates don't have histones!?!?!
And BEAUTIFUL microscopy.
How do fungi grow directionally? We think part of the mechanism involves local translation of mRNA near the tip, especially of cell wall components. Delighted to share our preprint showing that an RNA-binding protein, SsdA/Ssd1, is trafficked to the tip of growing fungal filaments.
Look out for Domenico, whose next destination is a postdoc with @samreckpeterson.bsky.social !
The Reck-Peterson group's work on cargoes hitchhiking on endosomes, and their discovery of adaptors PxdA and DipA, inspired some of this story showing that mRNA-protein complexes also hitchhike.
Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com
www.nature.com/articles/s41...
Below a short🧵 with the key findings!
Edward Wallace
I worked for UKRI for seven years and in my experience, the short timescales were 100% because of delays in central government. Usually because of delays in sign off by a minister; in the worst cases, due to number 10 comms teams insisting we hold back so the PM could announce it or whatever. 1/3
The Daum Lab
Edward Wallace
Ugh...
The work is a tour-de-force from the PhD of @dmodaffari.bsky.social, co-supervised with Edinburgh colleague Ken Sawin. Domenico set up Aspergillus nidulans in the lab, did beautiful hypothesis-driven imaging experiments, and generally learned everything from everyone then did it even better.
Save the date : Seminar by Edward Wallace from the University of Edinburgh on Tuesday 12th May at 11h @ewjwallace.bsky.social @edinburgh-uni.bsky.social
