WRF Fellow w/ @jshendure.bsky.social & @leastarita.bsky.social | @uwgenome.bsky.social, @cegs-cmap.bsky.social & @brotmanbaty.bsky.social | PhD w/ @edwardmarcotte.bsky.social | Musician, vinyl collector, RCB & Utd fan outside the lab. Mostly in that order.
Riddhiman Garge
Excited to see @riddhiman.bsky.social's gastruloid multiomics paper out now at Nature Cell Bio!
Riddhiman used proteomics, phosphoproteomics, and RNAseq to profile stem-cell-derived embryo models to identify protein, complex, and signaling regulators of development.
www.nature.com/articles/s41...
Previously a #preprint, now a peer reviewed @dschweppe.bsky.social work a fine, insightful, useful reference for the growing #gastruloid community . Proteomics, protein-RNA discordances, mouse-human comparison www.nature.com/articles/s41... Insights into human embryos for a growing #SCBEM community
How much of the human genome is essential?
Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome.
biorxiv.org/content/10.6...
nature.com/articles/d41...
☕ @riddhiman.bsky.social et al. use experimentally matched mass-spec and RNA-seq to quantify proteins, phosphosites & transcripts across 4 stages of human & mouse gastruloid development. @jshendure.bsky.social @leastarita.bsky.social @nobuhamazaki.bsky.social @dschweppe.bsky.social
bit.ly/4dAYyA1
A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.
