Elihu Professor of Biostatistics @yalesph.bsky.social--Cancer, Infectious disease, Evolutionary biology, Fungi, sometimes running
Jeffrey Townsend
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www.dropbox.com/scl/fi/23eeb...
visited our new "blue" Lincoln Monument reflecting pool.
2/n Intramolecular epistasis is increasingly recognized as an important feature of adaptive protein evolution. But how do adaptive amino acid substitutions actually accumulate? Do epistatically interacting substitutions fix sequentially, or do favorable combinations assemble before fixation?
1/n Check out our new paper, spearheaded by @fborne.bsky.social, just out in PLoS Genetics doi.org/10.1371/jour....
They are indeed. Source: literally me (and a whole bunch of other authors from multiple datasets)
I am recruiting PhD students for my new lab housed in the Sam Noble Museum at University of Oklahoma! If you are interested in fish macroevolution, geometric morphometrics, specimen-based research & phylogenomics please reach out. More info here: fishdiversitylab.weebly.com
Please share widely!!!
Politics is entitled to determine the topics and targets for public investment of funds. But the science to be done to accomplish those goals is best decided on by scientists.
White House seeks to tighten political oversight of grantmaking | Science | AAAS www.science.org/content/arti...
New @plos.org-GENETICS:
Borne, Taverner & @pandolfatto.bsky.social use MASS-PRF to detect clustered, lineage-specific amino-acid substitutions in Drosophila proteins—then beautifully validate one case in Trio.
journals.plos.org/plosgenetics...
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#EvoDevo
Older adults benefit from COVID-19 vaccine protection that keeps pace with waning immunity. Nursing home resident data show that antibodies decline substantially over the 12 months after vaccination, supporting biannual vaccine updates for adults 65+.
www.sciencedirect.com/science/arti...
Every cancer case can be associated with a genetic “fingerprint” shaped by both inherited vulnerabilities and acquired mutations. @yalemedicine.bsky.social: an open-access tool to quantify pathway-level disruption and advance personalized cancer risk assessment.
medicine.yale.edu/news-article...
