New paper alert 🚨 from @cgemcci.bsky.social showing high-resolution cryo-EM structures and mass spectrometry data that help us understand how beta-hydroxy acids are accommodated and incorporated by the ribosome!
Chandrima Majumdar
Check out our new paper using mass spectrometry and cryo-EM to show ribosomal incorporation and accommodation of β-hydroxy acid stereoisomers, bringing us closer to ribosomal synthesis of non-natural polymers. @c-majumdar.bsky.social @jhdcate.bsky.social
pubs.acs.org/doi/10.1021/...
Engineering the translation apparatus to accept backbone-modified amino acid analogues would enable the programmed synthesis of sequence-defined biopolymers with tunable properties. β-Hydroxy acids ar...
