More information about the paper: bsky.app/profile/alis...
Alissa Hummer
Our work exploring the ability of and requirements for ML to predict the effects of mutations on antibody-antigen binding affinity (ΔΔG) is out now in @natcomputsci.nature.com!
Alissa Hummer
Out now! @alissahummer.com @opig.stats.ox.ac.uk
and colleagues present Graphinity, a method to predict change in antibody-antigen binding affinity (∆∆G). Also featuring synthetic datasets of ~1 million FoldX-generated and >20,000 Rosetta Flex ddG-generated ∆∆G values!
www.nature.com/articles/s43...
Predicting the effects of mutations on antibody–antigen binding is a key challenge in therapeutic antibody development. Orders of magnitude more data will be needed to unlock accurate, robust predicti...
