A new paper in which we could contribute structural insights to the great biochemical work from our collaborators from UNC Chapel Hill. Sascha Amann from our lab was yet again able to solve several very challenging structures. This time of a SCF with Protac and target www.nature.com/articles/s41...
Compound-mediated targeted protein degradation through the recruitment of Ub ligases is an emerging field. Here, the authors determine key structural and biochemical principles for harnessing SCF-FBXO...
www.nature.com
Haselbach Lab
Cells have a built-in cleanup system to remove unwanted proteins, and scientists can hijack it to destroy cancer drivers. Now, researchers from our Haselbach lab and collaborators reveal how this works in near-atomic detail: https://www.nature.com/articles/s41467-026-72235-9
