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Just published: copper(II) binding to Human Serum Albumin. 1st structure including the ATCUN site that is square planar as expected. There are multiple copper(II) sites and EPR (including hyperfine and pulse dipolar) reveals occupation of multiple sites at low loading. doi.org/10.1039/D6QI...
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Copper homeostasis is essential for mammalian physiology. Serum albumin plays an important role in plasma copper transport and buffering, yet its Cu2+ binding sites have remained incompletely characte...
Crystallographic and EPR-based characterisation of Cu2+-binding to serum albumin: ATCUN coordination and additional sites
Bela Bode