Grateful to share our study on the potential for immune checkpoint blockade in late-onset #AlzheimersDisease out @nature.com today. Co-led with Kimi, Zhuoran, Ahad @kuchroolab.bsky.social in a big team effort @genelayinstitute.bsky.social @broadinstitute.org @harvardmed.bsky.social /1
www.nature.com
The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.
