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New paper out! chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... We introduce pseudoglucosinolates (psGSLs): a bioresponsive platform for enzyme-triggered release of isothiocyanates (ITCs). Enables covalent protein labeling (lysine-selective) in vitro & in vivo. #ChemicalBiology
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chemistry-europe.onlinelibrary.wiley.com
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase-responsive psGSLs. These compounds represent a complementary prodrug strat....
Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases
Philipp Klahn