We are extremely happy to share our latest publication on peroxiredoxin heterooligomerisation. A wonderful collaboration with the labs of Marcel Deponte, Joris Messens, Jan Riemer, and many others.
5/ Heterooligomerisation is inducible in response to oxidative challenge in yeast and stabilises Tsa1 as a Tsa1-Tsa2 heterodecameric complex.
With Armindo Salvador, we determined that it is possible to form as many as 120 distinct heterodecameric complexes with two monomeric components.
Morgan Lab
8/ 8/ The work now begins to understand the functional implications of peroxiredoxin heterooligomerisation and its implications for our current view of these fascinating proteins.
6/ With @riemerlab.bsky.social we could also show the presence of PRDX1-PRDX2 heterooligomers in HEK293T cells.
3/ Long considered to only form homooligomeric complexes, we find that pairs of peroxiredoxins from human, yeast, plant and parasite readily assemble into heterodimers and heterodecamers.
4/ With the Messens lab, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.
We are looking for a new colleague in the biology department at Saarland University!
We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.
Please share!
jobs.zeit.de/jobs/w2-prof...
Cells may work with “Lego®️ bricks” 🧱 at the molecular level. Our new study shows that peroxiredoxins can mix different subunits to form hybrid complexes arranged in donut-like rings 🍩, creating molecular diversity that helps cells fine-tune stress and redox signaling responses. Out in Nat Chem Biol.
Morgan Lab
Morgan Lab
Morgan Lab
www.nature.com/articles/s41...
Morgan Lab
Morgan Lab
Morgan Lab
Morgan Lab
Cells may work with “Lego®️ bricks” 🧱 at the molecular level. Our new study shows that peroxiredoxins can mix different subunits to form hybrid complexes arranged in donut-like rings 🍩, creating molecular diversity that helps cells fine-tune stress and redox signaling responses. Out in Nat Chem Biol.
