Group Leader @ibmb-csic.bsky.social
Filming single cell behavior during embryonic development. Interested in mechanics and immunity.
Esteban Hoijman
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1/4 What if in vivo apoptotic cell fragmentation is not autonomous, but is carried out by resident phagocytes? Check how this can improve tissue clearance in our recent paper from the Hoijman and Poon labs. @ibmb-csic.bsky.social @latrobeuni.bsky.social
www.science.org/doi/10.1126/...
1/4 What if in vivo apoptotic cell fragmentation is not autonomous, but is carried out by resident phagocytes? Check how this can improve tissue clearance in our recent paper from the Hoijman and Poon labs. @ibmb-csic.bsky.social @latrobeuni.bsky.social
www.science.org/doi/10.1126/...
4/4 We found this mechanism using early zebrafish embryos and mouse thymuses. It may help avoid inflammation during homeostatic or developmental cell turnover.
Want to image cells protecting the embryo during early development? We're hiring! 1 Postdoc, 1 PhD student, and 1 Research Technician. Come to Barcelona! www.embryobioimaging.com
Thanks for the comment of our paper in @science.org . Our first encounter in development with other organisms.
Thanks for the comment of our paper in @science.org . Our first encounter in development with other organisms.
3/4 Both fragmentation and phagocytosis are size-sensitive, with small targets favoring phagocytosis and large targets favoring fragmentation. Therefore, reducing apoptotic cell size by phagocyte-mediated fragmentation improves the efficiency of tissue clearance.
2/4 Assumed to be intrinsic to apoptotic cells, fragmentation into apoptotic bodies can be performed by Actin-rich protrusions from phagocytic cells, which split apoptotic cells into smaller phagocytic targets.
Mi artículo @muyinteresante.com sobre el primer encuentro entre embriones humanos y bacterias
www.fundacionmuyinteresante.org/embrion-defe...
Now at The Node
Early embryos develop... and eliminate threats thenode.biologists.com/early-embryo...
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Un hallazgo clave para entender la fertilidad y la salud reproductiva: un embrión es capaz de defenderse de bacterias.
We recently discovered that early embryos can eliminate bacterial infections before immune cells are formed. Take a look at the dynamics of our first encounter with microbes.
