A compelling shift toward tissue-centric immunity: lymphoid niches don’t just initiate responses—they time and constrain them. Brilliant now work from Lukas Altenberger shows that timing of initiating and terminating immune response are equally important.
www.science.org/doi/10.1126/...
The generation of effector CD8+ T cells (TEFF) requires activation of naïve CCR7+ T cells (TN) by dendritic cells (DCs) in lymphoid tissue. How TN-DC interaction duration and signal integration are co...
