Thanks to Hannah @wastyk.bsky.social & Will at InterfaceBio for advice on sactipeptides, and to the authors of AlphaFold 2 & 3, ESMFold, Boltz-1 (@gcorso.bsky.social), and more!
š Link to paper: biorxiv.org/content/10.1...
š» Link to code: github.com/rlacombe/Sac...
biorxiv.org
Evolution-based protein structure prediction models have achieved breakthrough success in recent years. However, they struggle to generalize beyond evolutionary priors and on sequences lacking rich ho...
