Neuroscientist looking at life through lenses. Running a lab when not teaching physiology. Passionate about optogenetics, imaging, synapses and neuromodulation. Otherwise:🏃🚴🎵
www.umm.uni-heidelberg.de/medical-faculty-mannheim/neurophysiology
Simon Wiegert
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Happy to have contributed to this beast of a paper with some optogenetics and fiber photometry.
...been doing this already a lot ;) Very easy
Simon Wiegert
Simon Wiegert
www.nature.com/articles/s41...
Two-author papers are always special.
Using optogenetic stimulation of hippocampal synapses in awake mice and tracking them over approx. 2 weeks, we link synaptic strength, spine volume and their stability. It's confirmed: bigger spines are stronger and more stable 😅
In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...
www.nature.com
Inaugural lecture to the faculty of Yasin Dagdas (@plantophagy.bsky.social) and Simon Wiegert (@simwieg.bsky.social) - bridging green and red biology.
Dopamine ≠ reward but turns out, also not the learning molecule we thought.
If DA RPE is the emperor, this work SCREAMS it was running naked all the time.
This paper got quite some attention recently. Let's simplify it a bit.
A🧵with my toy model and notes:
#neuroskyence #compneuro #NeuroAI
COS Heidelberg
Universität Heidelberg: Hörsaal- und Lernzentrum audiMAX wird feierlich eröffnet – Neuer zentraler Ort für Lehre, Lernen und Austausch auf dem Campus Im Neuenheimer Feld www.uni-heidelberg.de/de/newsroom/...
#universität #heidelberg #uniheidelberg #studium #lehren #lernen #campus #architektur
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science www.science.org/doi/10.1126/...
Kudos to everyone involved for pushing the boundaries of what we can see in the brain🚀
Check out the full paper here: doi.org/10.1038/s415...
Christopher Ford Andrew Yee @anitaluthi.bsky.social @labluthi.bsky.social @simwieg.bsky.social @FellinLab @ruemcclammyhand.bsky.social digersarah.bsky.social
neurosock
Universität Heidelberg
Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...
🚨 8 PhD positions in GPCR signaling! The research group “DynOrg"(@dfg.de, @simwieg.bsky.social) is hiring doctoral researchers to study how GPCRs shape brain, heart & behavior – combining optogenetics & physiology. 🌍 7 labs across Germany
🗓️ Apply by Aug 31, 2025
👉 www.for5807.de/en/open-posi...
Kevin Mitchell
Mannheim Center for Translational Neuroscience
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
www.science.org
Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...
Kudos to everyone involved for pushing the boundaries of what we can see in the brain🚀
Check out the full paper here: doi.org/10.1038/s415...
Christopher Ford Andrew Yee @anitaluthi.bsky.social @labluthi.bsky.social @simwieg.bsky.social @FellinLab @ruemcclammyhand.bsky.social digersarah.bsky.social
doi.org
Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
