🚨New in PNAS: www.pnas.org/doi/abs/10.1...
Genetic principal components (PCs) are commonly used to adjust for population stratification in genetic studies.
In this paper, we quantify how much direct genetic signal is lost when using these “catch-all” adjustments. 🧵
Contemporary genomic studies of complex traits, such as genome-wide association studies
and polygenic index (PGI) analyses, frequently include the ...
