Adaptation of Enterococcus faecalis to intestinal mucus revealed by a human colonic organoid model
#mSystems from Alexandre Persat
with @kimingeneva.bsky.social
journals.asm.org/doi/10.1128/...
Gut microbiota interactions with mucus during early intestinal colonization are critical for establishing stable communities and influencing host health. Using human colonic organoids combined with Tn-seq and live imaging, this study reveals how Enterococcus faecalis adapts to the mucosal surface by forming microcolonies and reprogramming its metabolism. This integrative approach provides a powerful platform to study other microbiota members in the native-like environment of the large intestine and evaluate potential therapeutic interventions.
