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by @jimpick.com
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This was a great collaboration with our UMN chemistry team and @mayoclinic.org collaborators, including Vijay Shah ad Harmeet Malhi @umnchemistry.bsky.social
Apr 16, 2025
And its finally out! Check out my recent article investigating the role of BRD4 in inflammation. But what excites me the most: we explore the safety side of things, and reduce the risk of BET side effects by >50 fold through more selective molecules. pubs.acs.org/doi/10.1021/... #chemsky
Apr 15, 2025
pubs.acs.org
BET bromodomain inhibitors demonstrate significant promise as anti-inflammatory agents. However, clinical data demonstrated that nonselective BET bromodomain inhibitors led to significant dose-limitin...
Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease
Cole Scholtz