Ground-breaking studies reveal the mechanism of "natural CRISPRa" 🤩
Looking forward to seeing all the technological applications !
Interested in autoinflammatory diseases? Read our review on Variants of Uncertain Significance (VUS) in @natrevrheum.nature.com with @alessandracarbone.bsky.social, Guilaine Boursier & Sinisa Savic. How to decode VUS through genetic, in silico, functional approaches and clinic! rdcu.be/fkOJM
IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...
🎉 We are thrilled to share our latest study revealing a new mechanism by which Legionella pneumophila evades antibiotic killing via reversible genetic variation mediated by integrative and conjugative elements (ICEs).
📖 Here for the full story:
www.biorxiv.org/content/10.6...
PAPER ALERT!
I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity.
www.cell.com/immunity/ful...
I would like to thank all the co-authors for their valuable contributions.
Well done guys!
Link for short summary below👇
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Université Grenoble Alpes has opened a full professorship in microbiology. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. For more information 👉🏻 liphy.univ-grenoble-alpes.fr/sites/defaul...
The Trojan Horse is real, and it’s microscopic! 🐴🦠
Our paper is out today in @cellcellpress.bsky.social!
We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇
www.sciencedirect.com/science/arti...
Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...
Thomas Henry
Thomas Henry
Personnic Lab
François Rousset
Jakub Began
Wilfling Lab
Viroscope
Ellen Foxman
Victor de Lorenzo (CNB, Madrid)
IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...
The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis
and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced
GTPase GBP1 pr...
Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
Rhinoviruses are the most frequent cause of common colds and also a major cause of
respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected
nasal epithelial organo...
Nature Reviews Rheumatology - In this Review, the authors discuss novel approaches to improving the functional classification of variants of uncertain significance that are associated with systemic...
Out now! In collaboration with Leifu Chang, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems!
Links to the published articles:
tinyurl.com/55kpavet
tinyurl.com/sk6djwx3
Previous thread for the preprint:
bsky.app/profile/did:...
Sternberg Lab
1/10 New pre-print(s) from the Sternberg Lab in collaboration with Leifu Chang's Lab! We uncover the unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs.
Full story here:
www.biorxiv.org/content/10.1...
