Professor of Immunology, Department of Pathology, University of Cambridge.
Research interests: PI3K, immunity, infection, cancer, immunotherapy.
Klaus Okkenhaug
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These are not a ranking lists we should be topping...
royalsociety.org/-/media/poli...
Nobel prize for Tregs!
www.nobelprize.org/prizes/medic...
Time to retire?
www.nature.com/articles/s41...
"We present The AI Scientist, which creates research ideas, writes code, runs experiments, plots and analyses data, writes the entire scientific manuscript, and performs its own peer review".
Klaus Okkenhaug
Klaus Okkenhaug
Klaus Okkenhaug
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field
www.annualreviews.org/content/jour...
Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).
Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...
Listen to James Edgar @campathology.bsky.social discuss cosmetic use of exosomes on BBC Radio 4 Inside Health: www.bbc.co.uk/sounds/play/...
(Spoiler alert: he does not approve).
Editorial @jimmunol.bsky.social @klausokken.bsky.social
Not just another kinase: the many roles of PI3K-δ in adaptive immunity
academic.oup.com/jimmunol/art...
Adrian Liston
Klaus Okkenhaug
Adrian Liston
Klaus Okkenhaug
Klaus Okkenhaug
Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.
Waggoner Lab
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
An artificial intelligence system can produce research papers with minimal human involvement, even passing the first round of peer review for the workshop of a main machine learning conference.
FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues,...
Today we have published a new analysis of UK immigration costs, comparing the 2025 costs of skilled worker, researcher and student visas in the UK and 17 other leading science nations. This updates previous analysis from 2019, 2021 and 2024:
royalsociety.org/news-resourc...
The Royal Society
The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...
PI3K transmit signals from receptors by phosphorylating phosphoinositides on the inner leaflet of the plasma membrane. PI3K enzymatic activity was first de
