Second preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity)
doi.org/10.64898/202...
Kresten Lindorff-Larsen
New preprint!
Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability.
We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.
Rasmus Hartmann-Petersen
Mapping the GCK-GKRP interaction landscape using deep mutational scanning by reverse two-hybrid screening https://www.biorxiv.org/content/10.64898/2026.01.15.699699v1
