The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)
Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation
doi.org/10.1101/2025...
Kresten Lindorff-Larsen
The importance of UBQLN2 ubiquitylation for its turnover and localization https://www.biorxiv.org/content/10.1101/2025.10.02.679934v1
