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PostDoc in @Merkling_lab x @InstitutPasteur within Insect-Virus Interactions @LambrechtsLab I 🦟 x 🦠Metabolomics & Single-cell @EMN_MetSoc committee
Thomas Vial
Silencing a key gene in this pathway (ahcy) enhanced the replication of dengue virus in mosquito cells. 🦠This revealed a new antiviral hub that could be targeted for vector control. Huge thanks to the team, especially co-first @sumeyye-ozhan.bsky.social & our PI @merklinglab.bsky.social ! 🙏
We identified the larval stage as a potential metabolic hotspot! 🐛 The methionine cycle appears to be a central metabolic hub, suggesting a high capacity for methylation. 🧬 (We even profiled the larval food!) #Metabolomics #Epigenetics
5mo
5mo
Kicking off the new year with mosquitoes, metabolomics, & arboviruses! 🥳 🦟Our new preprint is out! We mapped the metabolism of the Aedes aegypti mosquito across its life cycle to find new ways to fight dengue virus. Check it out on: doi.org/10.64898/202... #VectorBiology #Metabolomics #Mosquito
5mo
Thomas Vial
Thomas Vial
Developmental transitions in the mosquito Aedes aegypti are central to vector competence and disease transmission, yet the underlying metabolic programs remain poorly defined. Here, we use untargeted ...
doi.org
Stage-resolved metabolomics reveals the methionine cycle as a key regulator of Aedes aegypti development and dengue virus susceptibility
Thomas Vial
🦟❓How do mosquitoes respond to a bloodmeal at the #SingleCell level ? Please have a look at pre-print biorxiv.org/content/10.1... and website aedes-cell-atlas.pasteur.cloud to find out and look at your favorite cells and genes ! #Aedesaegypti
Nov 12, 2024
🏛️ Congratulations to our researchers honored in the France 2030 frameworks PEPR MIE (led by ANRS MIE) & PEPR PREZODE! 🏅 PEPR MIE Flash Call: Nadia Naffakh & Léonard Heyerdahl 🏅 PEPR MIE Junior Chairs: Marine Petit & Thomas Vial 🏅 PEPR PREZODE: Katherine Worsley‑Tonks 👉 anrs.fr/financements...
4mo