Researching ways to improve performance, prevent injuries, and accelerate recovery.
Keith Baar
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🧪A couple of key findings:
1. GLP-1 agonists (and dual agonists) don't cause significantly more muscle loss than calorie restriction alone.
2. Strength relative to body weight goes up both in mice and humans.
3. The extra lean mass loss seen in human trials comes from the loss of fat from the liver. Since on DXA the liver is considered lean mass and the liver mass decreased up to 50% with dual agonists, this could explain the 40% lean mass loss number from human trials.🧪
4. The GLP-1RA induced a significant increase in diverse mitochondrial proteins relative to caloric restriction.
There is a lot more coming on this topic, but the initial read is that GLP-1RA drugs are good for the liver and muscle.🧪
So, even though we want these patients to exercise, we need to realize they are much more likely to have serious tendon injuries when they do activity.
This suggests that people with kidney disease have weak tendons, even before they get corticosteroids and other drugs known to weaken them further. In fact, a third of all spontaneous tendon ruptures happen in people with kidney disease.
Honored that our recent paper on how caffeine altered adaptation to exercise was picked for APSselect. 🧪
journals.physiology.org/apsselect
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I had a great chat with the two Bens @proteomicsnews.bsky.social and @benneely.com about all things muscle and tendon. Check out our and let me know if you have any questions.
🧪 In our latest paper, my great student Christopher Hayden fed rats a small amount of adenine, which crystalizes and causes kidney disease.
The paper's new finding was that tendon quality decreased significantly in both males and females.
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Keith Baar
🧪New collaborative paper with the new lab of @henninglanger.bsky.social
Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans: Cell Reports Medicine www.cell.com/cell-reports...
