Happy to share that David and I have a new review out in @annualreviews.bsky.social of Biochemistry!
We break down Pol II pausing, its evidence in vitro/in vivo, and its two key fates which are in kinetic competition: pause release vs premature termination.
www.annualreviews.org/content/jour...
A signature feature of transcription on most genes in multicellular animals is that RNA polymerase II (RNAPII) piles up approximately 50 bases downstream of the start site at the promoter-proximal pau...
