This natural product study started in 2018 and it took us a while to understand these #sponge #knottins! Peptides in deep-sea sponges are super interesting but challenging 😅 Congrats to the Gunasekera Lab in Uppsala 🙌
Knottins are stable, structurally constrained mini-proteins with diverse bioactivities. This work presents the first report of a novel family of knottins, ‘stryphnines’, from the deep-sea sponge Stryp...
