Jones et al. analyzed two high-quality genomes of the cockroach genus Cryptocercus, the sister group to all termites, revealing relaxed selection in both Cryptocercus and termites.
🔗 doi.org/10.1093/gbe/evag028
#genome #evolution #sociality
Whale evolution makes me uncomfortable
Latest work! 🧬
We uncover how evolution of translation initiation factor 2 (IF2) extensions links translation to bacterial stress response. We map 7 structural architectures & show how terminal extensions are enriched in intrinsic disorder & phase-separation features.
Link: doi.org/10.64898/202...
Happy to announce that our paper on orphan gene evolution in bacteria dropped in PNAS yesterday!
This is a problem I've been thinking about since the start of my PhD. Very grateful for this journey, as well as All The Friends I Made Along the Way.
Also, Eid Mubarak to those who celebrate!
Equivariance is dead! 😢
Or is it? 😈
Genie 3 is out! Our latest protein design model achieves SoTA results for binder design and motif scaffolding, greatly improving on BindCraft and Proteina-Complexa.
It does so using all-atom SE(3)-equivariance based on a branched polymer representation👇
Join us the last time before the summer break! Cesar A. Ramirez-Sarmiento will talk about "Unveiling the fold-switching behavior of RfaH: echoes of the past, signals of the present". As always, Tue 5PM CET, follow the link to sign-up: tinyurl.com/prose-seminar2
Our next speaker will be Timothy Fuqua @timothyfuqua.bsky.social with "The Evolution and Emergence of Regulatory DNA", 14th April, 5PM CET.
Sign-up here:
tinyurl.com/prose-seminar2
Our next Talk will be "Protein Origami and the Hidden Rules of Functional Innovations"! March 11th, 5PM CET. Sign-up here: tinyurl.com/prose-seminar2
Patel, @lacholt.bsky.social et al. perform cross-species gene swap assays in D. melanogaster testes, showing that several orthologs of orphan gene Gdrd have undergone lineage-specific evolutionary changes.
🔗 doi.org/10.1093/molbev/msag119
#evobio #molbio #drosophila
Join ProSe next week Tuesday, when Noelia Ferruz @noeliaferruz.bsky.social is talking about "Controllable Protein Design with Protein Language Models and Reinforcment Learning", TUE, May 12, 5PM CET!
Sign-up here:
tinyurl.com/prose-seminar2
Abstract. Subsociality and wood-eating or xylophagy are understood as key drivers in the evolution of eusociality in Blattodea (cockroaches and termites),
Abstract. Orphan genes evolve rapidly, raising questions about whether their functions remain conserved or diverge across species. To address this, we inve
Introducing Genie 3, a generative protein model that substantially advances the state-of-the-art for binder design, increasing in silico success rates by up to 20x on hard multimeric targets. It also debuts a form of inference-time scaling unobserved in other design models. 🧵1/8
