Asymmetric cell division | Microscopy tech development | Synthetic biology | Fly models |
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Derivery Lab - MRC LMB
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MRC Laboratory of Molecular Biology
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
James Manton
James Manton
Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
🚨🚨🚨Check out this new preprint from the Löwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! 🚨🚨🚨
We are very happy that the amazing PhD work of our previous PhD student, @akaashkumar.bsky.social is out in Nature Photonics!
Steven has joined us as an RA to assist in the design, production and characterization of a panel of binders to be used as biosensors to image sorting of endogenous cargos in cells using multispectral microscopy, or as modulators of activities of sorting machineries!
Welcome to the lab, Steven!
MRC Laboratory of Molecular Biology
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
Derivery Lab - MRC LMB
Derivery Lab - MRC LMB
Derivery Lab - MRC LMB
Derivery Lab - MRC LMB
It was an absolute honour to win the #BSCB poster prize at #DynamicCellVI ! Its my first ever dynamic cell and I already can't wait for the next one!
Make sure to come to our other talk today on using this tech to study endosomal dynamics?
Meg Clapperton
A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...
Check out this preprint from the @simonbullock11.bsky.social lab, amazing work led by @lucas-albacete-x2.bsky.social ! 🔬
We've recently updated our multispectral microscopy manuscript to clarify a few points (particularly regarding SNR) and add eight supplementary figures. Courtesy of Sjoerd Stallinga, we now also have a derivation of the appropriate Cramér–Rao lower bound!
www.biorxiv.org/content/10.1...
Derivery Lab - MRC LMB
James Manton
Maximising imaging volumes of expanded tissues for inverted fluorescence microscopy https://www.biorxiv.org/content/10.1101/2025.09.12.675899v1
