Physics and biology of microbial communities. Structure, function, evolution. Center for the Physics of Evolving Systems. Dept. of Ecology and Evolution. UChicago. @NITMB, @CLS. kuehnlab.org
SeppeKuehnLab
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Global epistasis is observed everywhere from proteins to ecosystems, yet we don't know why. The effect of a perturbation such as a mutation or addition of a species on fitness or function depends linearly on the fitness or function in the absence of the perturbation.
SeppeKuehnLab
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These patterns arise generically from competition for shared resource pools, and deviations from this pattern can be interpreted as the presence of non-trivial ecological interactions impacting community function.
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Despite how widely it appears across biological scales, the mechanisms giving rise to it are unclear. In a new preprint I propose a simple mechanism for the observation of global epistasis in ecosystems.
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...since the latter requires probing high-dimensional compositional landscapes that appear to disguise low-dimensional processes governed by resource exchange or competition.
New preprint! www.biorxiv.org/content/10.6...
A theory to explain global epistasis in microbial communities
SeppeKuehnLab
4/5
I suggest that similar mechanisms might underlie global epistasis in organismal fitness. The result supports the notion that the structure and function of ecosystems might be simpler to understand from the perspective of resources than community composition,
A new preprint with Matthew Schmitt, @kiseokmicro.bsky.social and Vincenzo Vitelli makes a huge step forward in learning functional groups of components in complex biological systems. It's dimension reduction that speaks to biological function. www.biorxiv.org/content/10.6...
