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Immune cell recruitment, glycocalyx, chemokines and extracellular matrix at the Manchester Centre for Cell Matrix research and Lydia Becker Institute for Immunology he/him https://www.wellcome-matrix.org/people/doug-dyer/ #glycotime
Doug Dyer
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#glycotime
1mo
Doug Dyer
Some useful public speaking tips from Freud here.
Please get in touch if you have comments or are keen to explore collaborations to run your samples or establish this technique in your own core facility!
This approach has been deliberately designed to help break down barriers to glyco-matrix investigation by developing a technique with commercially available comsumables and minimising the use of chemicals prohibits by health and safety rules (specifically in the UK).
1mo
1mo
1mo
This is enabled by, and fulfills, the key aims of our @mcrcellmatrix.bsky.social @wellcometrust.bsky.social funded discovery research programme that will break down the wider barriers to studying the extracellular matrix!
delighted to share our new pre-print developing label-free glycosaminoglycan analysis of diverse complex biological samples, led by @h-davies-s.bsky.social working closely with David Knight and Rebecca Miller alongisde our recent recruit Samie Dalgarno www.biorxiv.org/content/10.6...
With extensive step by step protocols detailed here www.protocols.io/view/collect...
1mo
1mo
Anna Mazzola
1mo
Doug Dyer
Doug Dyer
New pre-print *finally* out! We've developed ToF-SIMS for in-situ glycosaminoglycan (GAG) analysis. Here's why that matters 👇📄 (1/9) www.biorxiv.org/content/10.6...
Long-lived CD163+ and Tim4+ gut macrophages in the lamina propria are spatially restricted by TGF-β rupress.org/jem/article/... @jem.org @tovah-shaw-lab.bsky.social @edinburghuni.bsky.social @manchesterup.bsky.social
Doug Dyer
Doug Dyer
1mo
We are proud to announce the discovery of Glyco-Carbohydrates, a paradigm shift in glycobiology! Traditional glycoconjugates (proteins, lipids & RNA) max out at 50% carbohydrate. Ours are 100% carbohydrate AND glycans, unlocking truly homogenous properties. TBA April 1st, 2027! 🍬 #glycotime
Doug Dyer
1mo
2mo
Waggoner Lab
Lorna Milne