Group leader in Bartos lab
| In-vivo 2P imaging, spatial memory and cortico-hippocampal networks |
Thibault Cholvin
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And much more in the paper, e.g.:
· MEC inputs often encoded multiple objects, while GCs preferentially encoded single objects
· Running speed information is conveyed by MEC (not LEC) inputs and is sparsely represented in GCs
I’m happy to share our new paper (with @mbartos.bsky.social) now out in Nature Neuroscience:
"The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations"
Download it @ rdcu.be/famDE
More below 🧵
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🧠 Opportunity for a PhD position: Studying interneurons and memory, using cutting-edge techniques, such as patch-clamp electrophysiology, in vivo calcium imaging, optogenetics and behavioral experiments.
Interested? Have a look here for more information:
www.fens.org/careers/job-...
We combined longitudinal 2-photon calcium imaging of LEC axons, MEC axons, and DG granule cells (GCs) in mice navigating virtual environments over 5 consecutive days. This allowed us to compare cortical inputs and hippocampal output directly.
2/ Accordingly, decoding of spatial location and context improves over days in GCs but not in EC inputs:
We show that the dentate gyrus (DG) does not simply relay entorhinal inputs. Instead, it gradually transforms LEC/MEC signals into sparse, highly specific and reliable multimodal representations of the environment.
3/ LEC and MEC deliver very different information to the DG. In a multisensory VR task, we found a striking division of labor:
· LEC→DG: mainly odor
· MEC→DG: objects, reward, space
· GCs: integrate and converge these streams into multimodal, highly specific representations
1/ Entorhinal inputs are fast while DG codes are slow to emerge. Representations in LEC/MEC emerged rapidly, already on day 1, and stayed relatively stable. In contrast, DG granule cell representations improved gradually across days of experience:
Thibault Cholvin
Nora Jamann
The DFG Senat is addressing a substantial (in some cases existential) problem we are currently facing in German life science www.dfg.de/en/service/p...
Excited to share that our IN-CODE interneuron research is featured in NANO, the science program from ZDF! Big thanks to Max Lebsanft and @mbartos.bsky.social for bringing neuroscience to a wider audience!
www.zdf.de/video/magazi...
