"a PRS is not an internal predisposition waiting to be realized; it is a risk estimate derived from a model constructed from population-level DNA associations without clearly defined biological mechanisms."
Philip Ball
With @remyfurrer.bsky.social, a new piece in Nature Human Behavior. The standard description of a polygenic score as a "genetic predisposition" essentializes a statistical construct. It's not language policing: PGS are a new kind of entity; now is the time to think carefully about what they are.
Nature Human Behaviour - Polygenic risk scores are not genetic predispositions
