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Happy to share our new review on biophysical principles of cell competition and elimination: www.cell.com/trends/cell-... With @bladoux.bsky.social and @rmmege.bsky.social, we discuss mechanical fitness, how loser cells are removed through various strategies and how forces can effect their fate

Hello epithelia enthusiasts! I’m @inesfournon.bsky.social and I study epithelial mechanics in sea anemones 🪼 Did you know epithelial cell extrusion had never been described outside bilaterian animals before? Well… not anymore 👀 Read ⬇️🧵1/9

Really happy to share my PhD story about the regulation of developmental speed in the Drosophila eye 🪰😃👀, which is now published @embojournal.org: link.springer.com/article/10.1... Grateful to everyone who make this possible, particularly F. Schweisguth @pasteur.fr @devstempasteur.bsky.social

We are happy to share our new bioRxiv pre-print on A-P axis patterning. A great collaboration with Felix Zhou (UT Southwestern) & the Yeomans group (Physics, Oxford) www.biorxiv.org/content/10.6...

New paper in Advanced Materials! We present DNA hydrogel microparticles for 3D tissue engineering, showing programmable material properties and cell-material interactions! Special thanks to Eleni Dalaka @gflaesch.bsky.social @kgoepfrich.bsky.social @xaviertrepat.bsky.social doi.org/10.1002/adma...

Spectacular Developmental Biology Jacques Monod Conference in Roscoff. Thanks to @bardinlab.bsky.social and @lionlchristiaen.bsky.social for putting together such an exciting scientific program. And the setting was incredible too, with a beautiful sunset to end the meeting.

Happy to share our new paper on collective cell dynamics. Great work from Yuan Shen @ijmonod.bsky.social ! Dynamic heterogeneity and hidden fluidity in dense epithelial tissues | Science Advances www.science.org/doi/10.1126/...

Our new review on epithelial barrier homeostasis has been published in Trends in Cell Biology(www.cell.com/trends/cell-...)! Please use the following link for free access until May 1: authors.elsevier.com/a/1mlnq3QxxT...

Epithelia cover the body’s surface to form a barrier that segregates the internal body from the external environment. Tight junctions (TJs) seal the paracellular space and are crucial for the formatio...

Cell competition is a highly conserved mechanism through which cells with lower fitness levels than surrounding cells are actively removed from tissues. Differences in fitness may result from intrinsic tissue heterogeneity or be caused by differentiation, infections, or mutations. The resulting competition dynamics act as a key regulator of various biological processes during development and homeostasis. The underlying mechanical factors often remain unclear. Here, we discuss the biophysical principles of cell competition and elimination via extrusion or delamination. Recent advances have uncovered how fitness is determined by cellular mechanical properties, which can regulate winning or losing, and how cells use forces to outcompete each other. Furthermore, forces can influence the fate and direction of eliminated loser cells, which govern functional tissue development and disease progression.

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...

Here our latest work on how morphogens trigger tissue phase transitions to tune their own length-scales and time-scales - An exciting collaboration with @zhvas.bsky.social @dianakhorom.bsky.social Bernat Corominas-Murtra and heroic experiments by the incredible @cami-autorino.bsky.social @embl.org

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨ “A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶 🔗 www.biorxiv.org/content/10.1... #devbio #biophysics 🧵⤵️