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Microglia protect the fetal brain from Zika virus, while primitive macrophages and monocytes drive infection and inflammation, highlighting diverse immune roles. Plus other great insights. Great work from @stjohnlab.bsky.social www.cell.com/cell/abstrac...
Dec 28, 2024
Fetal microglia are protective against Zika virus, but primitive macrophages and monocytes promote neuroinflammation and are disease promoting. Different fetal immune and neuronal cell types are targeted by different Zika lineages.
www.cell.com
Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection
Clive McKimmie