Today in @nature.com we introduce INSTALL, which bypasses mammalian DNA immune sensing to enable non-viral DNA integration with recombinasesāa step toward safe, and mutation-agnostic genome editing. š§¬ š§µ (1/13)
www.nature.com/articles/s41...
@harvardmed.bsky.social @mgbresearch.bsky.social
INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration strategies without ...
