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Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
www.nature.com
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
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Todd Douglas