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Cancer Research UK Scotland Institute (formerly the CRUK Beatson Institute). Our Mission: Cancer discovery for patient benefit. www.crukscotlandinstitute.ac.uk
Cancer Research UK Scotland Institute
⌛️There is still time to register for #BICC2026 "From Tumour Genesis to Metastasis: an immune perspective" Don't miss out on the chance to hear from our fantastic speakers, including keynotes from Frances Balkwill, John Wherry and Karin de Visser! www.beatsonconference.org/
MAPK-driven epithelial cell plasticity underlies colorectal cancer therapeutic resistance: Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy nmgn.mrc.ukri.org/news/mapk-dr...
Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology nmgn.mrc.ukri.org/working-grou...
1mo
4mo
4mo
Hooke Medal winner Stephen Tait @mitosrus.bsky.social @cruk-si.bsky.social is presented with his medal by BSCB president Laura Machesky before his fantastic medal talk on 'mitochondria, death and something in between' #DynamicCellVI
1mo
Cancer Research UK Scotland Institute
MRC National Mouse Genetics Network
MRC National Mouse Genetics Network
🚨Don't miss out! Early bird registration for #BICC2026 closes 1 April (10am BST) Join global leaders in cancer immunology in Glasgow this June 📍 @cruk-si.bsky.social, Glasgow | 📅 22-25 June #CancerResearch #Immunology 👇Register now👇
📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’ 📅22-25 June 2026 📍CRUK Scotland Institute, Glasgow 🎟️Early Bird registration closes on 1 April 🔗 www.beatsonconference.org #BICC2026 #CancerResearch #Immunology
2mo
3mo
🆕Paper from Naomi van den Berg (@naomiirisvdberg.bsky.social) in Cancer Cell proposes the "immunometabolic gatekeeping" framework to explain how tissue metabolism conditions tumour immunity @crick.ac.uk @cruk-mi.bsky.social @uofgcancersciences.bsky.social @cp-cancercell.bsky.social
We are delighted to announce that @mitosrus.bsky.social from @cruk-si.bsky.social @glasgow.ac.uk has been awarded the 2026 Hooke Medal You can read about Stephen's work on mitochondria, cell death and cancer here: bscb.org/hooke-medal-...
2mo
4mo
Cancer Research UK Scotland Institute
Cancer Research UK Scotland Institute
My first-author paper is out in @chemicalscience.rsc.org from my time in Professor Danny Huang’s laboratory @cruk-si.bsky.social. We showed that CBL can be used as a degrader E3 to target the “undruggable” eIF4E. pubs.rsc.org/en/content/a...
British Society for Cell Biology
Cancer Research UK Scotland Institute
4mo
British Society for Cell Biology
Video
Alice Wicks
(White et al., Cancer Research UK Scotland Institute and collaborators across the MRC National Mouse Genetics Network – Cancer Cluster) Colorectal cancer (CRC) is a genetically complex disease, yet re...
nmgn.mrc.ukri.org
www.beatsonconference.org
MAPK-driven epithelial cell plasticity underlies CRC therapeutic resistance | National Mouse Genetics Network
Beatson International Cancer Conference 2026
📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’ 📅22-25 June 2026 📍CRUK Scotland Institute, Glasgow 🎟️Early Bird registration closes on 1 April 🔗 www.beatsonconference.org #BICC2026 #CancerResearch #Immunology
3mo
Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the “immunometabolic gatekeeping” framework, whereby tissue-intrinsic metabo...
www.cell.com
Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity
Cancer Research UK Scotland Institute
Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that recruit an ubiquitin ligase (E3) and a neo-substrate into a ternary complex, enabling selective protein degradation. Desp...
pubs.rsc.org
CBL ubiquitin ligase targets translation as a degrader E3