Biophysics@MRC Laboratory Molecular Biology, Cambridge
All opinions are my own
Stephen McLaughlin
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Hope you can join us for our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk in September. We have a fantastic speaker line up: www3.mrc-lmb.cam.ac.uk/sites/nextge...
Today I'm posting a new blog about an astonishing scientific own goal. Hundreds of papers have reported using a totally wrong antibody to investigate the tumor suppressor p16. This mistake has happened because scientists have muddled the names of two proteins.
forbetterscience.com/2026/06/02/m...
Online Now: TRIM21 induces selective autophagy of viruses and bacteria Online now:
The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year.
Applications are open now!
More details: mrclmb.ac.uk/careers-and-...
Please share this post with anyone who may be interested!
Assembly and phospho-regulatory mechanisms of the budding yeast outer #kinetochore KMN complex. New study from Noah N. Turner (@noahnturner.bsky.social), David Barford and colleagues @mrclmb.ac.uk:
rupress.org/jcb/article/...
#CellDivision #StructuralBiology #kinetochores #centromeres #cryoEM
Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4).
www.nature.com/articles/s41...
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social.
Available now on BioRxiv: doi.org/10.64898/202...
Reluctant to post too much about this but I did want to share my favourite finding from the dozens of manipulated or duplicated ThermoFisher verification blots. This one has a giant square. Enjoy!
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!
Stephen McLaughlin
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data.
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
The hidden rules behind mRNA transport.
A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs.
Read more: mrclmb.ac.uk/news-events/...
#LMBNews @cellbiol-mrclmb.bsky.social 🧪
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
Led by Investigator Scientist @hongmiaohu.bsky.social, @kellythd-nguyen.bsky.social’s group in the LMB’s Structural Studies Division have produced the first ever structure of telomerase from yeast.
Read more here: mrclmb.ac.uk/news-events/...
#LMBResearch #cryoEM 🧪
MRC Laboratory of Molecular Biology
Reese Richardson
Video
MRC Laboratory of Molecular Biology
New preprint! We asked a simple question:
How do very different activating adaptors all activate dynein?
Turns out: same architecture, wildly different implementations 🧵👇
doi.org/10.64898/202...
Rhinesmith et al. describe an intracellular antimicrobial mechanism called “antibody-directed xenophagy” (ADX). In ADX, the E3 ubiquitin ligase TRIM21 prevents infection by intercepting antibody-coated viruses/bacteria in the cytosol and orchestrating their destruction via selective autophagy. The authors hypothesize that ADX may be co-opted for targeted protein degradation.
