4/4 This work was a true team effort between @amolf-nl.bsky.social, IHB Basel, and the @Hubrechtinstitute.bsky.social — led by @danielkrueger.bsky.social and Kasper Spoelstra. Huge thanks to all collaborators for making it possible.
1/4 New in Science: Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process.
www.science.org/doi/10.1126/...
Do you want to learn how to make mouse thymus organoids?
Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue.
Read it here: doi.org/10.1016/j.xp...
#Thymus #Organoids #STARProtocol #TEC
The Clevers lab is in Spain! Our postdocs Hanxiao, @sarinashabso.bsky.social, @amandaanderssonr.bsky.social and a PhD student @katarinabalazova.bsky.social are taking part in an @embo.org Workshop on Liver and Pancreas in Metabolic Diseases in Girona 🌞 #embo #liver #pancreas #girona
2/4 Using live imaging, CRISPR myosin reporters, organoid villus substrates & optogenetics, we found that myosin-driven tissue tension—not compression—controls extrusion. Cells with reduced contractility are preferentially removed.
3/4 This reveals a safeguard mechanism: epithelial cells constantly test each other’s mechanical strength. Too little (or too much) force destabilizes the barrier, linking extrusion to diseases like tufting enteropathy. Gut renewal is an active, force-regulated process.
‼️New review by @amandaanderssonr.bsky.social and @hansclevers.bsky.social discussing the latest applications for organoids is now out in Nature Reviews Molecular Cell Biology: “New developments and applications of human organoids.” 🧫
🔗Read here: www.nature.com/articles/s41...
Our PhD student @samwillemsen.bsky.social presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025.
#ThymUS2025 #Organoids #Thymus
IFN-responsive intestinal BEST4/CA7+ cells are targets of bacterial diarrheal toxins @cp-cellstemcell.bsky.social @thecleverslab.bsky.social
www.cell.com/cell-stem-ce...
Organoids are powerful tools for studying human development and disease mechanisms in vitro. This Review discusses their limitations and recent advances that increase their complexity to better mimic ...
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
