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In this system, the mechanosensitive ion channel PIEZO1 is the sensor of compressive stress, and we suggest that it may be a useful biomarker to predict disease outcomes.Sarah has a more detailed narrative of our findings here: bsky.app/profile/drsa...
3mo
We are very excited to share our newest results, published in AAAS Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigene...
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We are very excited to share our newest results, published in AAAS Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via… | Sara...
Michael Samuel
We are very excited to share our newest results, published in Science Advances: “Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory”. doi.org/10.1126/scia...
3mo
Compressive force drives PIEZO1-RHO-ROCK mechanotransduction and establishes an epigenetic memory that promotes tumor progression.
Compressive stress–driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory
doi.org
Sarah Boyle