It's known that anionic lipid charge enhances alpha-synuclein's ability to bind membranes. But did you know that alpha-synuclein can preferentially bind to neutral membranes when they are full of packing defects?
Read about it in our latest preprint!
Wade Zeno
Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein https://www.biorxiv.org/content/10.1101/2024.11.14.623669v1
alpha-Synuclein (alphaSyn), an intrinsically disordered protein implicated in Parkinson's disease, i
