Please check out our forthcoming ICML paper on learning the BCR affinity maturation process, with applications in variant effect prediction and antibody design.
Yun S. Song
Antibody LMs learn what looks antibody-like, but not how selection turns naive germline antibodies into strong binders.
@aakarshv1.bsky.social and I are excited to share CoSiNE, a model that learns this germline-to-mature process for variant effect prediction and antibody design. (1/8)
