We study developmental epigenetics using fruit flies
https://www.su.se/english/research/research-groups/group-mannervik
Mannervik Lab
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Have you ever wondered how chromatin states shape developmental trajectories? In our preprint, we address this question using single-cell nanoCUT&Tag, a method developed by Marek Bartosovic @mardzix.bsky.social, which simultaneously profiles active H3K27ac and repressive H3K27me3 in the same nucleus
www.biorxiv.org
Mannervik Lab
Second, lineage-determining transcription factors are repressed in lineages where they are not expressed (as in the case of vvl). But the third pattern was the most unexpected.
Our interpretation is that these genes are active only in specific cell subtypes within that lineage. Polycomb repression likely acts in the other cells of the same lineage, preventing inappropriate activation.
Many genes were repressed by H3K27me3 only in one cell lineage, and this was often the same lineage in which the gene is normally expressed. How can a gene be both expressed and Polycomb-repressed in the same lineage?
