Very proud of this and so cool that enhancer-level models can predict the effect of genetic variation. There is so much personal variation in terms of gene regulation in the human brain, it is fantastic to uncover this thanks to technology (whole-genome sequencing and single-cell multiomics) and AI
Stein Aerts
1/
𧬠Happy to share our new preprint on modeling cis-regulatory variation in human brain enhancers across a large Parkinsonās disease cohort: www.biorxiv.org/content/10.6...
Details in the thread below: