Assistant Professor at Baylor College of Medicine and Texas Children's Hospital. Houston, TX
Science: disorder, condensates, repeats, cell stress, neurodegeneration, drug discovery, synbio Non-science: art, fashion, cooking
www.boeynaemslab.org
Steven Boeynaems
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Four years of New-Bee, and every year the new faces still get me. New wonder, new questions, new sparks. We keep going. 🐝
Sincere thanks again to @rsb.org.uk — proud to have secured this year's Regional Events Grant on behalf of our committee.
Excited to share this collaborative work with Ward and Petrucelli Labs!
We show that two major genetic risk factors for #neurodegeneration and cognitive decline converge on TMEM106B fibrils accumulating within lysosomes.
A LOT of work packed in here 🧠🔬
Preprint: www.biorxiv.org/content/10.6...
Preprint 🧵!
I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition!
BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a
www.biorxiv.org/content/10.6... (1/6)
We're moving to Boston! Excited to share that I'm starting my own lab in the Neurobiology Department at Harvard Medical School in 2027!
Bacterial immune proteins have repeatedly evolved to become parts of eukaryotic immunity. But how?
Our new preprint uncovers a recent horizontal transfer event & shows how eukaryotes co-opted a toxic bacterial immune protein 🦠🧪🧵 1/
Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI
The algal pyrenoid fixes ~1/3 of global carbon, relying on a unique membrane-within-condensate architecture. How is this architecture built? We discovered that the protein MITH1 draws membranes into the pyrenoid condensate by promoting wetting! 🌿💧
www.biorxiv.org/content/10.6...
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Thrilled to see our Deep-Phase paper now online in
@cellcellpress.bsky.social! 🎉 The final version expands Deep-Phase across labeling modalities, adds dual-condensate imaging to dissect pathway specificity, and shows greater robustness to batch effects than classical image-analysis methods.
Excited to share a new preprint, led by @yasmeen-hamed.bsky.social! It describes a mechanism and potential therapeutic avenue for treating the aging bladder! Thanks to the amazing collab from the Beyder lab, as well as @valeriavasquez.bsky.social, Lichtarge labs! www.biorxiv.org/content/10.6...
Guo-Teng
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral
condensate morphology to reveal underlying biochemical states. Applying this framework
reveals a previously unrecogn...
www.cell.com
www.biorxiv.org
Furqan Fazal
Kevin Guttenplan
Tera Levin
Martin Jonikas
Christine Mayr
Anita Donlic
Kara Marshall
Nature Protocols - This Protocol describes the transcriptome-wide labeling of RNAs in a particular subcellular compartment using proximity biotinylation by localized APEX2 enzyme and subsequent...
Another successful New-Bee 🐝 neuro program in the 📚! We were delighted to host Elkins HS for a day of neuroscience demos and lessons. The future is bright with these future STEM leaders! 🤩 Special thanks to generous support from @bcmneurosci.bsky.social and @rsb.org.uk.
