This is a working link to the preprint! www.biorxiv.org/content/10.6...
Much thanks to my supervisor and collaborators! Thank you for reading the thread :)
Silencing these NbNOI genes causes NbPtr1-dependent lethality.
(4/6)
Crucially, this suppression requires direct protein-protein interaction—and bacterial effectors disrupt this very interaction to trigger plant immunity! 💥
(5/6)
A new preprint is OUT! 🚨
Thrilled to finally share our work on how decoy diversification underpins the regulation of an NLR-mediated autoimmunity.
Check out the full story on @bioRxiv: www.biorxiv.org/content/10.6...
(1/6)
RIN4 & NOI proteins are well-conserved in land plants. We propose that non-orthologous NLRs have independently evolved to guard the NOI protein family. 🌿
NOI protein diversification provides a brilliant convergent mechanism for NLRs to detect diverse pathogen effectors! 🔬 (6/6)
NbPtr1 is an NLR from wild tobacco that recognizes multiple sequence-unrelated effectors from Pseudomonas, Xanthomonas, and Ralstonia. 🦠
These effectors all target RIN4. But what is the molecular basis of NbPtr1's expanded recognition?
(2/6)
NbPtr1 alone is autoactive, inducing cell death. By investigating N. benthamiana RIN4 orthologs and NOI-domain proteins, we found 5 small NOI proteins (not orthologous to RIN4) that suppress this NbPtr1-induced cell death. 🛡️
(3/6)
Ye Jin (Jennie) Ahn
Ye Jin (Jennie) Ahn
Ye Jin (Jennie) Ahn
#2027ISMPMI - Try 2 for Jeju, Korea!
Hope to see you there and I’m glad that South Korea gets to host after their turn was missed because of the pandemic.
There is a promise of good food 🤤
Though I may need to start saving up now with the state of things…
#2025ISMPMI
Ye Jin (Jennie) Ahn
Ye Jin (Jennie) Ahn
#2025ISMPMI has been great, so many connections made and re-established. I found this on the railway bridge.
