Postdoctoral researcherer at #TheUstunLab in @ruhr-uni-bochum.de working on P-bodies and bacterial pathogens.
🏳️🌈 he/him
Manuel González Fuente
Loading...
Congrats to everyone involved every step of the way, and special thanks to @suaybuestuen.bsky.social for initiating this project and for all the support throughout the journey 🙏🏻
Who would have thought, five years ago when I first looked at P-bodies under the microscope, that this journey would lead here. 🔬
Very happy to see this work finally out in #ScienceAdvances. Proud of this collaborative effort and grateful to everyone involved. 👏🏻🎉
Manuel González Fuente
And if you want to quickly know more about it, here's a small thread we wrote when it was first preprinted 🧵
Thrilled to see my main PhD project finally online @MolCell !! 🥳🌱🧬
If you want to know how the plant proteasome activators are sorted in a proteasome-dependent manner and how they coordinate transcriptional response during proteotoxic stress, please have a read ! 🤓
www.cell.com/molecular-ce...
Manuel González Fuente
Manuel González Fuente
🌱Update on our preprint "𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘢𝘴 𝘢 𝘴𝘱𝘢𝘵𝘪𝘢𝘭 𝘰𝘳𝘨𝘢𝘯𝘪𝘻𝘦𝘳 𝘰𝘧 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺"
www.biorxiv.org/content/10.6...
1) 🧬 mesophyll autophagy rescues ETI; guard cell autophagy does not
⚡ PTI competence likely requires autophagy across tissues—not just in mesophyll or guard cells.
Gautier Langin
Here’s the press release by @ruhr-uni-bochum.de for our newest publication 🧬✨
“Bacteria use P-body condensates to attenuate host translation during infection”
How pathogens rewire host translation via condensates 🔄🌱
#plantscience #proteostasis
www.science.org/doi/10.1126/...
Preprint alert 🚨 (1/10) 🧵
𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘪𝘴 𝘢 𝘱𝘢𝘳𝘢𝘥𝘰𝘹 𝘪𝘯 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺:
It can promote resistance, susceptibility, or restrict cell death 🤯
So what is its actual role?
We show it acts as a spatial organizer of immunity across cell types 🌱🦠 #proteostasis
www.biorxiv.org/content/10.6...
New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵
Our work is out now! (www.science.org/doi/10.1126/...). We discover a selective autophagy pathway that protects plants from the mess caused by RNA viruses. Intrigued? Follow the spaghetti trail for a summary of our findings🧵-->
🚨 Paper out now in #ScienceAdvances @science.org 🌱🦠
Pathogens don’t just target protein degradation—they also hijack host translation.
"Bacteria use P-body condensates to attenuate host translation during infection" ⚖️♻️
led by @manuelgonzalezfuen.bsky.social
www.science.org/doi/10.1126/...
Bacteria deactivate the protein synthesis of host cells to hamper immune reactions. This insight could aid in the development of more resistant plants.
RNA viruses co-opt host endomembranes to form replication complexes, often triggering cellular stress and immune responses. Here, we show that Arabidopsis thaliana activates selective autophagy to res...
Preprint alert 🚨 (1/10) 🧵
𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘪𝘴 𝘢 𝘱𝘢𝘳𝘢𝘥𝘰𝘹 𝘪𝘯 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺:
It can promote resistance, susceptibility, or restrict cell death 🤯
So what is its actual role?
We show it acts as a spatial organizer of immunity across cell types 🌱🦠 #proteostasis
www.biorxiv.org/content/10.6...
