Cool paper from Rebecca Heald lab! "Triploid brain cells are less proliferative but do not exhibit differences in transcription" (me: !!) www.sciencedirect.com/science/arti...
Neuron size varies significantly over evolution, contributing to diverse nervous systems of variable complexity, while aberrant neuron size is associa…
Neuronal size varies across evolution, diseases, and brain regions. It has long been regarded as a descriptor, not a driver of function. Using triploid Xenopus, Liu et al. show that neuronal enlargement remodels neurite geometry, reduces proliferation, increases phospho-extracellular signal regulated kinase (pERK) responses, and alters behavior, linking cellular scaling to brain function.
