In this study, Guang Yang & co analyse more than 150 cell lineages from newly generated whole-genome duplication cells and find that fewer than 10% of lineages survive long term.
journals.biologists.com/bio/article/...
Vertebrate #Hedgehog signaling is transduced by transmembrane protein Smoothened (SMO) on the primary #cilium, but what is its mechanism? @reitergroup.bsky.social &co show that SMO & ciliary GPCRs regulate ciliary PKA activity to activate the Hedgehog pathway @plosbiology.org 🧪 plos.io/4v7vdnp
Reminder — UW #Microbiology has an open search for an Assistant Professor, focusing on fundamental problems in #bacteriology!
If you or someone you know would be suitable, here's the ad:
apply.interfolio.com/185622
Interested in how #fungi came about on this planet? If so, take a look at my new article that just came out in @annualreviews.bsky.social.
doi.org/10.1146/annu...
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature.
Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
I expect this paper is great, but I really do not like the way the eukarya are represented in this image
I for one like the idea of limiting the number of R01 type grants a lab can have to help diversify the research being done. However, the data (a little out of date) says this is not the problem. The issue is ever decreasing $ to the NIH in inflationary dollars.
The Department of Microbiology & Immunology is looking for a new Assistant Teaching Professor to join us at the UMN!
hr.myu.umn.edu/psc/hrprd/EM...
We published an article written by a number of current and former peer review workers in their personal capacities outlining the changes to peer review at the NIH over the last 18 months. It’s a great resource, and we’re grateful to the authors who wrote it! open.substack.com/pub/27unihte...
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Fungi are widespread on our planet and essential for life as we know it, but how did they come about? Their last common ancestor lived hundreds of millions of years ago, but its characteristics, and t...
Authored by anonymous current and former NIH workers with experience in peer review, this is an overview of all the changes to NIH's peer review over the last 18 months.
open.substack.com
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
Talk of limiting grants, by number or by dollars, should be informed by data. It’s been a long time since we got NIH information on grants per PI.
drugmonkey.scientopia.org/2013/01/30/p...
This figure was posted by Sally Rockey, head of the Office of extramural research on her blog Rock Talking. We have discussed these data in the past but given my recent Fixing the NIH series of pos…
